Effect of Bacterial Translocation on Haemodynamic and Coagulation Parameters During Liver Transplantation

Alexandria University30 enrolled

Overview

The present study is to demonstrate the effect of the presence of bacterial translocation detected by bacterial deoxyribonucleic acid (bactDNA) in blood and ascites using the polymerase chain reaction (PCR) on some haemodynamic and coagulation parameters during a liver transplant procedure.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Effect of Bacterial Translocation

Interventions

PCR for bacterial translocationDIAGNOSTIC_TEST

samples taken from the blood and ascites of patients to search for bacterial DNA

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: • patients with liver failure undergoing liver transplantation Exclusion Criteria: * Age less than 18 years; * Active overt infection; * Patients on oral or systemic anticoagulation or with known coagulopathic disorders apart from those caused by liver failure (eg.: Protein C or S deficiency, congenital platelet disorders and congenital coagulation disorders…etc); * Patients undergoing re-transplantation.

Locations (1)

Elmoasah Hospital

Alexandria, Egypt

Outcomes

Primary Outcomes

change in the mean arterial blood pressure

Time frame: at the beginning of surgery then 15 nim after dissection then 15 min after the anhepatic phase then 15 min at the reperfusion phase

antifactor X activity

Time frame: at the beginning of surgery

change in the heart rate

Time frame: at the beginning of surgery then 15 nim after dissection then 15 min after the anhepatic phase then 15 min at the reperfusion phase

change in the cardiac output

Time frame: at the beginning of surgery then 15 nim after dissection then 15 min after the anhepatic phase then 15 min at the reperfusion phase

Data from ClinicalTrials.gov

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