Eealy Improvement Predicts Antidepressants Response in Adults With Major Depression Disorder

Huashan Hospital80 enrolled

Overview

Early improvemrnt, decreased 20% in the 17 items of Hamilton Depression Rating Scale (HAMD-17) at the second week of the treatment of major depression disorder (MDD), can arguably predict the remission at the 12th week. Our observation study including 80 MDD patients will access resting-state function MRI to finding factors which infuencing early improvemrnt, respone and remission of antidepressants.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Major Depressive Disorder

Interventions

antidepressantDRUG

regular one-drups treatment of selective serotonin reuptake inhibitor(SSRIs)

Eligibility

Sex: ALLMin age: 16 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * right-handed; HAMD-17 more than 17; diagnosed with MDD by the Structured Clinical Interview for DSM-IV Exclusion Criteria: * patients diagnosed with other condition in DSM-IV Axis I; pregnency; Thyroid disease; Heart Disease

Locations (1)

Dept. of Neurology, Huashan Hospital, Fudan University

Shanghai, Shanghai Municipality, China

RECRUITING

Outcomes

Primary Outcomes

Early improvement

obtain 20% decrease of HAMD-17

Time frame: the second week of treatment

Secondary Outcomes

Response

obtain 50% decrease of HAMD-17

Time frame: the 12th week of treatment

Central Contacts

Shi Shenxun, PhD

CONTACT

13816203171 shishenxun@163.com

Data from ClinicalTrials.gov

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