The Effect of Adding Dexamethasone to Epidural Bupivacaine for Total Knee Replacement Surgery

Assiut University50 enrolled

Overview

The purpose of this study was to evaluate the efficacy of dexamethasone when added to epidural bupivacaine on the duration of postoperative analgesia in patients underwent total knee replacement surgery.

Fifty patients underwent total knee replacement were included in the study. The patients (11 male and 39 female) were classified into two equal groups:- The patients received 15 mL plain bupivacaine + 2 mL (BS), or 8 mg dexamethasone (BD). The total volume injected in both groups was 17 ml. Postoperative records: 1. Pain score (NRS) at base line, then every 4 hrs for 24 hrs. 2. Frequency of rescue analgesia. 3. Postoperative side effects like nausea, vomiting, and over sedation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Postoperative Pain

Interventions

DexamethasoneDRUG

dexamethasone + plain Bupivacaine injected epidurally.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients scheduled for total knee replacement surgery. 2. ASA Physical status I,II,III. Exclusion Criteria 1. Patients' refusal. 2. Uncooperative patients / Not able to understand pain assessment test. 3. Patients with history of allergy to the used drugs. 4. Significant liver disease. 5. Pregnancy. 6. Any contraindication for epidural anesthesia 7. Failed technique.

Outcomes

Primary Outcomes

duration of postoperative analgesia (NRS)

first patient request for analgesia or NRS 4 or more

Time frame: 24 hrs postoperative

Data from ClinicalTrials.gov

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