Rt-PA Thrombolytic Therapy in Combination With Remote Ischemic Conditioning for Acute Ischemic Stroke

Inclusion Criteria: * Male or female, age≥18; * Acute ischemic stroke; * modified Rankin Scale (mRS) score of 2-5; * mRS score less than 1 before onset of stroke symptom; * Onset of stroke symptoms within 4.5h before initiation of intravenous rt-PA thrombolytic therapy; * Good compliance for Remote Ischemic Conditioning(RIC) therapy; * Informed consent obtained. Exclusion Criteria: * Stroke or serious head trauma within the previous 3 months * Major surgery or severe trauma with in the preceding 3 months * Intracranial hemorrhage * Systolic pressure greater than 185 mm Hg or diastolic pressure greater than 110 mm Hg, or aggressive treatment intravenous medication) necessary to reduce blood pressure to these limits * Symptoms rapidly improving * Symptoms suggestive of subarachnoid hemorrhage, even if CT scan was normal * Gastrointestinal hemorrhage or urinary tract hemorrhage within the previous 21 days * Arterial puncture at a noncompressible site within the previous 7 days * Seizure at the onset of stroke * Platelet count of less than 100,000 per cubic millimeter * Received heparin within the 48 hours preceding the onset of stroke and had an elevated partial-thromboplastin time * Received oral anticoagulation therapy preceding the onset of stroke and INR greater than 1.7 or prothrombin times greater than 15 seconds * CT showed a multiple infarction (low density area greater than 1/3 cerebral hemisphere) * Use or plan to use intervention for diagnosis or treating * Intracranial neoplasm, cerebral aneurysm or arteriovenous malformation * severe hepatic or renal dysfunction * Contraindication for remote ischemic conditioning: severe soft tissue injury, fracture, or peripheral vascular disease in the upper limbs. * Life expectancy\<1 years * Pregnant or breast-feeding women * Unwilling to be followed up or poor compliance for treatment * Patients being enrolled or having been enrolled