ZnPP is being build in the case of a functional iron deficiency. Zinc instead of iron is implemented into protoporphyrin IX. This ZincProtoporphyrin (ZnPP) can be detected non invasively. Non invasive and invasive optical measurement of ZnPP will be compared. Additionally ZnPP measurements will be compared to other iron deficiency parameters for validation by the investigators.
Zinc-protoporphyrin (ZnPP) will be measured by a fluorescence technique. Restricted wave light (407/425 nm) is used to detect ZnPP in the bloodstream non-invasively through the oral mucosa. The spectroscopic measurements are translated into a ZnPP value (mumol/mol heme). The non-invasive measurement of ZnPP is validated and compared to optical measurement of ZnPP in whole blood and high performance liquid chromatography (HPLC) measurement of ZnPP in whole blood. The ZnPP value is compared to other iron-deficiency parameters: Ferritin, Transferrin saturation and soluble Transferrin receptor.
Study Type
OBSERVATIONAL
Enrollment
300
Within 30 seconds, a measurement is performed on the lip of a patient to determine a ZincProtoporphyrin value
University Hospital Zurich
Zurich, Switzerland
Validation of the non-invasive ZincProtoporphyrinIX measurement
The value is compared to optical measurement of ZincProtoporphyrin in whole blood; in addition the value is compared to HPLC measurement in whole blood
Time frame: Baseline
Comparison of the ZincProtoporyphyrinIX value to other iron-deficiency parameters
The value is compared to Ferritin, Transferrin saturation and soluble transferrin receptor
Time frame: Baseline
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