The primary reason the investigators are doing this study are to understand how the right side of the heart functions in heart failure patients with left ventricular assist devices (LVADs, or "mechanical hearts"). Second, the investigators are interested in understanding how different pacemaker settings influence function of the heart at rest and activity.
Healthy individuals, as well as patients with advanced heart failure supported by LVADs, completed invasive hemodynamic analysis at rest and with exercise to characterize right-sided heart function at rest and with exercise during invasive cardiopulmonary exercise testing on upright cycle ergometry.
Study Type
OBSERVATIONAL
Enrollment
22
University of Colorado Hospital
Aurora, Colorado, United States
Peak Vo2
peak Vo2 measured by indirect calorimetry during cardiopulmonary exercise testing
Time frame: 20 minutes
Cardiac Output
cardiac output measured during invasive cardiopulmonary exercise testing.
Time frame: 20 minutes
Blood Pressure
mean arterial pressure during exercise
Time frame: 20 minutes
Respiratory Exchange Ratio
Respiratory exchange ratio derived from indirect calorimetry
Time frame: 20 minutes
Minute Ventilation
Minute ventilation during cardiopulmonary exercise testing
Time frame: 20 minutes
Tau
unit of measure of diastolic function during exercise
Time frame: 20 minutes
Stroke Work
stroke work during exercise
Time frame: 20 minutes
EES/EA
ventricular arterial coupling during exercise
Time frame: 20 minutes
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