This study evaluates postoperative numerical pain score and systemic opioid requirement within 48 hours for unilateral total knee arthroplasty. Comparing among 3 groups of intrathecal morphine; 0,50, 100 ug with multimodal analgesia.
Intrathecal opioid is effective postoperative analgesia for orthopedic lower extremity surgery. However there are some limitations such as nausea, vomiting, pruritus, dizziness. Nowadays multimodal analgesia is used in unilateral total knee arthroplasty include oral analgesic drugs, adductor canal block and local analgesia infiltration. This study evaluates whether intrathecal opioid should be added in the role of multimodal analgesia in total knee arthroplasty.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
131
Spinal block with bupivacaine and intrathecal morphine 50 ug
Spinal block with bupivacaine and intrathecal morphine 100 ug
Spinal block with bupivacaine and intrathecal morphine 0 ug
Faculty of Medicine Siriraj Hospital, Mahidol University
Bangkok Noi, Bangkok, Thailand
Numerical rating scale
Numerical rating scale 0-10
Time frame: Within 48 hours
Morphine requirement
Systemic morphine requirement
Time frame: Within 48 hours
Nausea vomiting
Incidence and severity of nausea and vomiting
Time frame: Within 48 hours
Pruritus
Incidence and severity of pruritus
Time frame: Within 48 hours
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intrathecal morphine
0.5 isobaric bupivacaine