Constipated patients often have mental problems such as depression and anxiety due to difficult defecation. Our previous studies have proved the efficacy of FMT treating constipation. Meanwhile it is believed that mental diseases are correlated to gut microbiota. This trial is based on the theory of the gut-brain-microbiota axis. Patients with constipation, depression and/or anxiety are performed FMT, laboratory, imaging and microbiota examinations, and clinical follow-up, to observe the clinical efficiency of FMT and the potential role of gut microbiome in these gut-brain disorders.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
40
fecal microbiota transplantation
Department of Generay Surgery, Jinling hosptal, Medical School of Nanjing University
Nanjing, Jiangsu, China
RECRUITINGCSBMs per week
complete spontaneous bowl movements per week
Time frame: 12 weeks after treatment
HAMA
score of Hamilton Anxiety Rating Scale
Time frame: 12 weeks after treatment
HAMD
score of Hamilton Depression Rating Scale
Time frame: 12 weeks after treatment
Wexner
score of Wexner
Time frame: pre, 2 weeks, 4 weeks, 8 weeks, 12weeks
PAC-SYM
score of PAC-SYM
Time frame: pre, 2 weeks, 4 weeks, 8 weeks, 12weeks
Bristol Bristol PAC-SYM
score of Bristol score of Bristol
Time frame: pre, 2 weeks, 4 weeks, 8 weeks, 12weeks
PAC-QOL
score of PAC-QOL
Time frame: pre, 2 weeks, 4 weeks, 8 weeks, 12weeks
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