Study of Netarsudil Ophthalmic Solution in Subjects With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT)

Inclusion Criteria: 1. Must be 18 years of age or older 2. Diagnosis of open primary angle glaucoma(POAG) or ocular hypertension (OHT) in both eyes 3. Unmedicated intraocular pressure (IOP) \>20 mmHg and \< 30 mmHg in both eyes at first qualification visit 4. Best corrected visual acuity (BCVA) equivalent to 20/200 Snellen or better 5. Able to give informed consent and follow study instructions Exclusion Criteria: Ophthalmic: 1. Clinically significant ocular disease 2. Pseudoexfoliation or pigment dispersion component glaucoma, history of angle closure glaucoma, or narrow angles 3. Intraocular pressure ≥30 mmHg in either eye 4. A difference in IOP between eyes \>4mmHg at qualification visit 5. Use of more than two ocular hypotensive medications within 30 days of screening 6. Known hypersensitivity to any component of the formulation 7. Previous glaucoma surgery or refractive surgery 8. Keratorefractive surgery in either eye 9. Report of ocular injury in either eye within the six months prior to screening or ocular or non-refractive surgery within 3 months prior to screening 10. Recent or current ocular infection or inflammation in either eye 11. Use of ocular medication in either eye of any kind within 30 days of screening 12. Mean central corneal thickness greater than 620 μm in either eye 13. Any abnormality preventing reliable applanation tonometry of either eye 14. Lack of suitable episcleral vein prior to performing Episcleral Venus Pressure (EVP) measurement (applicable to 1 site only) Systemic: 15. Clinically significant abnormalities within 6 weeks prior to screening 16. Clinically significant systemic disease 17. Participation in any investigational study within 60 days prior to screening 18. Use of systemic medication that could have an effect on intraocular pressure within 30 days prior to screening 19. Women of childbearing potential who were pregnant, nursing, planning a pregnancy, or not using a medically acceptable form of birth control