Modulating Movement Intention Via Cortical Stimulation

NYU Langone Health30 enrolled

Overview

The purpose of this protocol is to learn about movement intention and volition. To improve such knowledge, investigators will conduct sub-studies using multiple non-invasive methodologies. These results could provide preliminary data for subsequent studies evaluating local and global efficacy of plasticity-inducing treatments for PMD symptoms.

This study will: * Explore effects of TMS and tDCS on movement intention. * Discern the neural activity underlying modulation of movement intention with neuroimaging recording. * Identify brain stimulation's effect in patients with psychogenic tremor and non-epileptic seizures. * Technical development of new experimental paradigms and data analysis methods. * Data collection for hypotheses development.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Seizures Seizure Disorder Psychogenic Movement Disorder

Interventions

Sham TMS3 stimulationDEVICE

half of the subjects will receive sham stimulation first

rTMS of left or right angular gyrus (AG) or frontal cortex (FC)DEVICE

Half of the subjects will receive active stimulation first; A subject may receive either TMS or tDCS stimulation, but not both, over the course of the sub-study.

Anodal tDCS of left or right AG or FCDEVICE

Half of the subjects will receive active stimulation first; A subject may receive either TMS or tDCS stimulation, but not both, over the course of the sub-study.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: (Healthy Controls) * Fluent in English (Patients with PMD or PNES): * Diagnosis of PMD/PNES confirmed by a neurologist with expertise in movement disorders. * Per the treating neurologist, subject is unlikely to require treatment and/or dosage changes for 3-6 months following screening Exclusion Criteria: * Any history of a significant neurological disorder, which may interfere with the interpretation of study data, as determined by the PI * Chronic or progressive medical condition * Any history of traumatic brain injury or significant head trauma * Currently meets criteria for substance abuse or dependence * History of any psychotic disorder or other psychiatric condition which may interfere with data interpretation * Pregnancy * Metal or devices in the head, including neurostimulators or metal foreign bodies * Any other implanted metal device, including pacemaker, spinal cord stimulator, VNS. * Any other ferromagnetic substance in the body that may increase study risk (including dental prosthetics, etc.). * Taking tricyclic antidepressant or antiepileptic medications or CNS active drugs under "strong potential hazard" list in Rossi et al., 2009 * Current diagnosis of any inflammatory or autoimmune disorder within last 6 months PMD and PNES Patients * Any history of traumatic brain injury or significant head trauma * Diagnosis of organic seizure disorder, including febrile seizures and tonic-clonic seizures; * Neurological disorder other than PMD and PNES including stroke, fainting spells or syncope of unknown cause(s); * Major or unstable medical illness, especially any current diagnosis of inflammatory or autoimmune disorders within last 6 months * Metal or devices in the head, including neurostimulators or metal foreign bodies * Taking tricyclic antidepressant medications or CNS active drugs under "strong potential hazard" list in Rossi et al., 2009; * Diagnosis of dementia, or Montreal Cognitive Assessment (MoCA) ≤24; * Recurrent visual hallucinations, within the past 6 months; * History of significant uncontrollable movements of the head; * Any clinically significant abnormality on vital signs

Locations (1)

New York University School of Medicine

New York, New York, United States

RECRUITING

Outcomes

Primary Outcomes

Changes in signal intensity measured using of tDCS

as a result of altering cerebral perfusion in response to neurophysiologic stimulation

Time frame: 30 Minutes

Changes in signal intensity measured during EEG recording

as a result of altering cerebral perfusion in response to neurophysiologic stimulation

Time frame: 3 Hours

Changes in signal intensity measured during MEG

as a result of altering cerebral perfusion in response to neurophysiologic stimulation

Time frame: 3 Hours

Central Contacts

Nalini Jeet

CONTACT

(212) 263-0228 Nalini.Jeet@nyulangone.org

Data from ClinicalTrials.gov

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