Study of cardiovAscular Contrasted Phenotypes in Patients With FamIliaI hypercholesteRolemia

Inclusion Criteria: * Patient agreeing to sign the consent of the study and the consent of biocollection * Patient suffering from a familial hypercholesterolemia with a clinically-biologic score DLCN (Dutch Lipid Clinic Network, Annex 2)\> 8 and / or a causative mutation identified in the LDL receptor genes, apolipoprotein B100 or Of PCSK9. * Men ≥ 40 years of age; Female ≥ 50 years * Patient affiliated to an existing social insurance The inclusion criteria to be met in the population with known coronary atheroma: * Subject in secondary prevention of an atheromatous disease: coronary event or ischemic heart disease, irrespective of the result of the coronary calcium score; Ischemic stroke with proven carotid atheromatosis; revascularization (angioplasty, bypass surgery) or amputation in PAD * Primary prevention topic CV with calcium score ≥ 400 Agatston units Inclusion criteria to be met in the population without cardiovascular risk: \- No cardiovascular event (including MI, coronary revascularization, angina, stroke \&, Transiant ischemic attack of atheromatous origin, PAD) with: For women between 50 and 65 years, a nil calcium score \* For women between 65 and 75 years of age, a calcium score\*\* ≤ 10 Agatston units For women over 75 years of age, a calcium score\*\* ≤ 20 Agatston units For men between 40 and 55 years of age, a nil calcium score\* for men For men between 55 and 70 years of age, a calcium score\*\* ≤ 10 Agatston units For men over 70 years of age, a calcium score\*\* ≤ 20 Agatston units * 40 year old men and 50 year old women: less than 6 months old * 41 year old men and 51 year old women: under 1 year old * 42 year old men and 52 year old women: under 2 years old * 43 year old men and 53 year old women: under 3 years old * 44 year old men and 54 year old women: under 4 years old * Less than 5 years Inclusion criteria to be met in the related population with familial hypercholesterolemia : * Patient agreeing to sign the consent of the study and the consent of biocollection * Patient suffering from a familial hypercholesterolemia with a clinically-biologic score DLCN (Dutch Lipid Clinic Network, Annex 2)\> 8 and / or a causative mutation identified in the LDL receptor genes, apolipoprotein B100 or Of PCSK9. * Men or Female ≥ 30 years * Patient affiliated to an existing social insurance Inclusion criteria to be met in the related population without familial hypercholesterolemia : * Patient agreeing to sign the consent of the study and the consent of biocollection * Patient not suffering from a familial hypercholesterolemia related to one of the members of the population suffering from familial hypercholesterolemia without cardiovascular risk * Men or Female ≥ 18 years * Patient affiliated to an existing social insurance Exclusion Criteria: * Subject suffering from active cancer or progressive neoplasia * Subject treated with recent corticosteroid therapy * Subjects with unsubstituted or poorly controlled hypothyroidism (TSH\> normal) * Subject receiving immunosuppressive or anti-cancer treatment * Subject refusing to participate * Subjects under tutelage, curatorship or a safeguard of justice or without social insurance The exclusion criterion for all populations except the related population without familial hypercholesterolemia: \- Subject with no "definite" familial hypercholesterolemia according to the DLCN score (≤8), after auction. The purpose of the auction will be to rule on the causal nature of an identified mutation.