Improving Post-Prandial Blood Glucose Control With Afrezza During Closed-Loop Therapy

Inclusion Criteria: * The age inclusion criterion is 18-29 years for phase I and 18-50y for phase II * Previously diagnosed with Type 1 Diabetes Mellitus, as determined by the judgment of the Principal Investigator, based on clinical presentation and as documented in the clinic record (formal antibody or genetic testing will not be required). * Diabetes duration at least 1 year. * Willing to have an intravenous (IV) line inserted for frequent blood sampling and infusion of glucose. * Hemoglobin A1c (HbA1c) ≤10% * Speak and understand English. Exclusion Criteria: * HbA1c \>10.0% at the time of screening * Insulin pump naïve subjects and subjects with unstable insulin dosing parameters requiring daily adjustments in insulin sensitivity factor, insulin to carbohydrate ratio and basal rates other than the established temporary rates that are determined to manage specific conditions such as exercise. * History of an episode of severe hypoglycemia or Diabetic Ketoacidosis (DKA) requiring inpatient management within six months prior to the screening visit and/or subjects with history of clinician diagnosed hypoglycemia unawareness. * History of recurrent DKA defined as more than three episodes of admissions for DKA during the past 12 months. * Subjects requiring an insulin total daily dose \<0.1u/kg/day and \>3u/kg/day. * History of physician diagnosis of asthma or any other clinically important pulmonary disease, or use of any medications to treat such conditions within the last year * Allergy or know hypersensitivity for Afrezza or to drugs with similar chemical structure * Any disease or exposure to any medication which, in the judgment of the principal investigator, may impact glucose metabolism. * FEV1 \<70% of NHANES III; Forced vital capacity (FVC) \< 70% of NHANES III predicted for children ≥8 years of age. * Positive urine pregnancy test for female patients of childbearing, breast feeding, or intention to become pregnant. * Smoking of tobacco or other substances. * Subjects who discontinued smoking (including cigarettes, cigars, pipes) within the past 6 months. * History of abnormal spirometry or chest X-ray suggestive of lung disease. * History of respiratory tract malignancy. * Any condition or medication that may result in pulmonary toxicity (e.g. current or previous chemotherapy or radiation therapy or history of or current use of amiodarone). * Inability to perform study procedures including pulmonary function testing and Afrezza inhalation using the BluHale system. * Patients who take acetaminophen containing medications on a regular basis or anticipate taking during the study period and are unable and/or unwilling to substitute with a non-acetaminophen containing medication. * Use of a device that may pose electromagnetic compatibility issues and/or radiofrequency interference with the DexCom CGM (implantable cardioverter defibrillator, electronic pacemaker, neurostimulator, intrathecal pump, and cochlear implants). * Active gastroparesis requiring current medical therapy. * Known bleeding diathesis or dyscrasia.