This is single center study. The investigators will try to know that relationships between intestinal microbiome and mortality in preterm infants and what relationships is between intestinal microbiome in preterm infants and morbidity, mortality.
Microbiome is the collection of all the microorganisms living in association with the human body which are consist of eukaryotes, archaea, bacteria and viruses. Microbiome in an average human body number are ten times more than human cells and have about 1000 more genes than are present in the human genome. There are symbiotic relationships between human and microbiome. If investigators are able to know about relationships between newborn and intestinal microbiome, mortality and morbidity in preterm infants may be improved. The investigators will collect the first and weekly stool of participants and analyze DNA of microbiome thorough Metagenomic anlysis. The results between 3 groups(preterm, late preterm and full-term infants) will be compared. The investigators expect that a mean distribution of intestinal microbiome in newborns(preterm, late preterm and full-term) is defined and that relationships between mortality, morbidity and intestinal microbiome.
Study Type
OBSERVATIONAL
Enrollment
120
Wonju Severance Christian Hospital
Wŏnju, Gangwon-do, South Korea
RECRUITINGIntestinal microbiome
The distribution rate of intestinal microbiome of stool by K-mer based taxonomic assignment which is one of the analysis in result of metagenomics in each infants
Time frame: for 2 years
Full Enteral feeding in preterm infants
Days to accomplish a full-enteral feeding in each infants
Time frame: for 2 years
Growth rate
Days to reach 2 kg of body weight in each infants
Time frame: for 2 years
Mortality
Number of patients who died in neonatal intensive care unit.
Time frame: for 2 years
Morbidity
Number of patients who had a complication of preterm infants(e.g. necrotizing enterocolitis, bronchopulmonary dysplasia) or were died in neonatal intensive care unit.
Time frame: for 2 years
Allergic predisposition
Number of patients who were developed a allergic predisposition at 6 month of postnatal age.
Time frame: for 2 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.