Multimodal Analgesia in Laparoscopic Radical Gastrectomy With Gastric Cancer: a Multi-center Study

Inclusion Criteria: 1. Requirements of informed consent and assent of participant, parent or legal guardian as applicable. 2. Patients underwent laparoscopic radical gastrectomy under general anesthesia and between the age of 18 and 75 years old without considering sex. 3. American Society of Anesthesiologists (ASA) physical status I-III. 4. Participants can follow the drug doses and visit plan Exclusion Criteria: 1. Patients certified by a doctor that doesn't fit to participate in this study. 2. Patients allergic to opioids, sulfas, parecoxib, non-steroidal drugs, acetaminophen, tramadol etc.. 3. Patients with ischemic heart disease, cerebrovascular disease and peripheral vascular disease, or their cardiac function \> II (NYHA) patients, patients received coronary artery bypass grafting (CABG) recently, and patients with severe hypertension (systolic pressure≥180mmHg or diastolic pressure≥110mmHg). 4. Patients with gastric cancer with distant metastasis. 5. Patients with severe infection, respiratory dysfunction, coagulation disorders, severe liver and renal dysfunction (Child - Pugh≥ 10; creatinine clearance \< 25 ml/min). 6. Patients with suspect or have a history of drug abuse. 7. Pregnancy and lactation women, or have a pregnancy plan within a month after the test of the subjects (also including male participants). 8. Sponsors or researchers directly involved in the testing or their family members. 9. Patients with conversion, palliative resection. 10. Patients with chronic pain（NRS≥3）or using opioids or NSAIDs before surgery.