Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation in the Treatment of Pancreatic Cancer

Inclusion Criteria: * PET-CT/EUS-FNA cytologically confirmed stage III -Ⅳ of pancreatic cancer * Between 18 and 80 years old * Karnofsky Performance Status (KPS) ≥ 70%，Guaranteed treatment for 3 months * Normal functions of heart, lung and kidney * Adequate hematological profile： Hemoglobin ≥ 9.0 g/dL、 Absolute granulocyte count ≥ 1,500/mm\^3 、Platelet count ≥ 100,000/mm\^3， start the treatment within 14 days after these results meet the requirements * A life expectancy \> 3 months * Informed consent signed * HLA-haplotype-matched immediate family health donors who have been confirmed by laboratory HLA genotypes * Interval the last anti-tumor treatment for more than 3 months Exclusion Criteria: * Highly allergic or people with severe allergies * Brain metastasis or Primary central nervous system malignancy * Suffer from clinical illnesses that affect clinical trials, including but not limited to： Uncontrollable diabetes；active infectious disease or uncontrollable infection; acute and chronic liver disease; confirmation of HIV infection; uncontrollable hypertension, symptomatic congestive heart-failure, unstable angina pectoris, and myocardial infarction, uncontrollable arrhythmia over the last 6 months. * Combined heart, lung, kidney and other vital organs dysfunction * A serious coagulation dysfunction, a clear history of other tumors * Pregnant and lactating women * Mental illness, affecting the compliance of clinical trials * The patient will participate in other trials within 10 days prior to the trial or While participating in other tests * Patients underwent weight loss by 10% and above within 6 weeks before the start of the trial * Neutrophils\<500mm\^3 or Platelet count\<50,000/mm\^3 * Need to drive and manipulate the machine during the trial Donor's Inclusion Criteria: * First-degree relatives of patients * Age\<55 years old * Normal functions of heart, lung and kidney * Adequate hematological profile： Hemoglobin ≥ 9.0 g/dL、 Absolute granulocyte count ≥ 1,500/mm\^3 、Platelet count ≥ 100,000/mm\^3、WBC≥ 3000/mm\^3， start collecting stem cells within 14 days after these results meet the requirements * Informed consent signed Donor's exclusion Criteria: * Highly allergic or people with severe allergies * The person who have history of atherosclerosis, venous thrombosis or autoimmune disease * A serious coagulation dysfunction, a clear history of other tumors * Infectious disease or carriers * Pregnant and lactating women * Mental illness, affecting the compliance of clinical trials * WBC\<4000/mm\^3、PLT\<70\*10\^9/L