A Phase 1 Study of ARN-6039

Inclusion Criteria: Only volunteers who met all of the following criteria were included as study subjects: * Male or female between 18 and 50 years of age, inclusive. * Female subjects were not pregnant or lactating. * Female subjects were postmenopausal (at least 2 years prior to dosing) or surgically sterile. Subjects who claimed postmenopausal status had their status confirmed with a follicle-stimulating hormone (FSH) test. Surgically sterile was defined as: Bilateral tubal ligation, hysterectomy, or bilateral oophorectomy at least 6 months prior to dosing; or Permanent sterilization (e.g., ESSURE procedure) at least 3 months prior to dosing. * Subjects had a body mass index (BMI) between 19 and 30 kg/m2 (inclusive) and weighed a minimum of 50 kg (110 lbs). * Subjects voluntarily consented to participate in this study and provided their written informed consent prior to start of any study-specific procedures. * Subject was willing and able to comply with all trial requirements. * Subject was willing and able to remain in the study unit for the entire duration of the confinement period and return for an outpatient visit 7 days after study treatment administration. * Subject's vital signs (measured sitting after 5 minutes rest) at screening were within the following ranges: heart rate: 40-100 beats per minute \[bpm\]; systolic blood pressure (BP): 90-145 mmHg; diastolic BP: 50-95 mmHg. Out-of-range vital signs could be repeated once. Predose vital signs were assessed by the Principal Investigator or designee (e.g., a medically qualified Sub-Investigator) prior to study drug administration. The Principal Investigator or designee verified the eligibility of each subject with out-of-range vital signs and documented approval prior to dosing. * Subjects had results within normal range on the following hematology tests performed at screening: hemoglobin, hematocrit, total and differential leukocyte count, and platelet count. * Subject had results that did not exceed the upper limit of normal range on the following liver function tests performed at screening: aspartate transaminase (AST), alanine transaminase (ALT), and total bilirubin. * If enrolled in Cohort 5 (the food-effect cohort), subject was willing and able to consume the entire high-calorie, high-fat breakfast meal in the designated timeframe required during the fed period. Exclusion Criteria: Volunteers who presented any of the following criteria were excluded as study subjects: * History or presence of clinically significant cardiovascular, pulmonary, hepatic, renal, hematologic, gastrointestinal (including cholecystectomy), endocrine, immunologic, dermatologic, neurologic, oncologic, or psychiatric disease or any other condition that, in the opinion of the Investigator, would likely have interfered with the absorption, disposition, metabolism, or excretion of the investigational product, or would have jeopardized the safety of the subject or the validity of the study results. * History of cancer with the exception of basal cell carcinoma or squamous cell (skin) carcinoma. * History of seizure (including febrile seizure) or loss of consciousness. * History of drug or alcohol abuse or dependence (based on the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria) within the past 2 years. * Donated blood or plasma or experienced significant loss of blood within 8 weeks prior to admission to the clinic, or planned to donate blood within 1 month after study participation. * Had a clinically significant abnormal finding on the physical exam, medical history, ECG, or clinical laboratory results at screening. * Had smoked or used tobacco or nicotine-containing products (e.g., cigarettes, cigars, chewing tobacco, snuff, etc.) within 30 days prior to the first dose of study medication. * History or presence of allergic or adverse response to ARN-6039 or related drugs or its excipients. * Had been on a significantly abnormal diet during the 4 weeks preceding the first dose of study medication. * Had participated in another clinical trial (randomized subjects only) within 30 days (or 5 half-lives of the investigational product) prior to the first dose of study medication. * Had used any over-the-counter (OTC) medication, nutritional or dietary supplements, or herbal preparations, (other than acetaminophen and/or multivitamins \[acetaminophen 2 grams/day and multivitamins were allowed up to 48 hours prior to dosing\]), within 7 days prior to the first dose of medication. * Had used any prescription medication, except hormonal replacement therapy, within 14 days prior to the first dose of study medication. * Consumed the following beverages or products within the specified time frame prior to admission to the clinic: Alcohol, grapefruit, Seville oranges (marmalade), xanthine, or quinine within 72 hours; or Caffeine or poppy seeds within 48 hours. * Had been treated with any known drugs that are moderate or strong inhibitors/inducers of cytochrome P450 (CYP) enzymes such as barbiturates, phenothiazines, cimetidine, carbamazepine, etc., within 30 days prior to the first dose of study medication and that in the Investigator's judgment may have impacted subject safety or the validity of the study results. * Had a positive urine screen for drugs of abuse (amphetamines, barbiturates, benzodiazepines, cocaine, cannabinoids, opiates) or cotinine. * Had a positive test for hepatitis B surface antigen, hepatitis C antibody, or human immunodeficiency virus (HIV) at screening or had been previously treated for hepatitis B, hepatitis C, or HIV infection. * Was, for any reason, deemed by the investigator to be inappropriate for this study, including subjects who were unable to communicate or cooperate with the investigator or designee. * Female with a positive pregnancy test result.