The purpose of this study is investigating the clinical course, treatment course, and prognosis of patients with interstitial lung disease.
Interstitial lung disease refers to pulmonary disease that occurs in the interstitium of the lung. It can be broadly classified into lung disease secondary to the cause of systemic disease or drug, and lung disease whose cause is unknown, and the latter is known as idiopathic interstitial pneumonia. Idiopathic interstitial pneumonia is a lung disease showing various aspects of inflammatory response and fibrosis reaction, and the cause of the onset is not accurately known yet, also there is no effective treatment. Idiopathic interstitial pneumonia, including idiopathic pulmonary fibrosis, progresses very slowly, but sometimes acute exacerbation without any obvious cause leads to death, rapidly. Therefore, it is important to collect data prospectively for changes in clinical features, pulmonary function, imaging findings, and quality of life of these patients. A prospective study of idiopathic interstitial pneumonia will provide important information on the clinical characteristics and admission history of patients with idiopathic interstitial pneumonia, and the idiopathic interstitial pneumonia registry system will serve as the basis for further prospective observational studies. The aim of this study is to establish the registry of patients with interstitial lung disease and to prospectively review the clinical features and progression of the patients.
Study Type
OBSERVATIONAL
Enrollment
300
For patients with interstitial lung disease, the investigators regularly monitor changes in clinical symptoms, pulmonary function, and chest radiography after basic questionnaire on symptoms, lifestyle, depression, and quality of life.
Seoul National University Hospital
Seoul, South Korea
RECRUITINGSt George's Respiratory Questionnaire(SGRQ)
monitoring changes in clinical symptoms
Time frame: at baseline, every 1 year through study completion for 10 years
modified Medical Research Council (mMRC) dyspnea scale
monitoring changes in clinical symptoms
Time frame: at baseline, after 1 month, after 3 month, and then every 1 year through study completion for 10 years
Borg dyspnea scale
monitoring changes in clinical symptoms
Time frame: at baseline, after 1 month, after 3 month, and then every 1 year through study completion for 10 years
Hospital anxiety and depression score(HADS)
monitoring changes in clinical symptoms
Time frame: at baseline, every 1 year through study completion for 10 years
chest X-ray
monitoring changes in chest radiography
Time frame: at baseline, after 1 month, after 3 month, and then every 1 year through study completion for 10 years
Chest CT
monitoring changes in chest radiography
Time frame: at baseline, every 1 year through study completion for 10 years
Paranasal sinus X-ray(PNS series)
baseline PNS X-ray
Time frame: at baseline
Electrocardiogram(ECG)
baseline ECG
Time frame: at baseline
Pulmonary function test with bronchodilator response test(PFT+BDR)
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monitoring changes in lung function
Time frame: at baseline, after 1 month, after 3 month, and then every 1 year through study completion for 10 years
Diffusing capacity of the lungs for carbon monoxide(DLCO)
monitoring changes in lung function
Time frame: at baseline, after 1 month, after 3 month, and then every 1 year through study completion for 10 years
total lung capacity(TLC)
monitoring changes in lung function
Time frame: at baseline
Bronchoscopic alveolar lavage(BAL)
for diagnostic purposes if necessary
Time frame: at baseline
Video-assisted thoracoscopic surgery(VATS) lung biopsy
for diagnostic purposes if necessary
Time frame: at baseline
echocardiography
additionally tested at acute exacerbation
Time frame: at baseline
arterial blood gas analysis(ABGA)
additionally tested at acute exacerbation
Time frame: at baseline