A Comparative Study of Sibling Oocytes: ICSI vs. the PICSI Sperm Selection Method

Hillel Yaffe Medical Center50 enrolled

Overview

The aim of this research is to compare sibling oocytes using two sperm selection methods for choosing the best quality spermatozoa before they are injected into oocytes and the influence of each of these methods on embryo quality and IVF outcome.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Infertility

Interventions

ICSI petri dishDEVICE

Half of the oocytes will be placed into the standard ICSI petri dish and they will be injected with sperm with normal morphology.

PICSI petri dishDEVICE

Half of the oocytes will be placed into a PICSI petri dish (whose bottom is coated with hyaluronic acid) and the mature spermatozoa with CD44 receptors that are attached to the bottom of the dish will be injected into them.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Males aged 18-60 * Females aged 18-35 * Males with mild OTA (oligo terato astheno zoospermia) and at least one failed IVF cycle * Males with normozoospermia with at least 2 unexplained failed IVF cycles * Females with normal FSH and normal AMH values * Females who have retrieved in previous cycles at least 6 oocytes Exclusion Criteria: * Couples who have been exposed to heavy smoking, drugs and chronic diseases * Males who have undergone testicular surgery (TESE) or defined as severe OTA * Females with egg factor infertility

Locations (1)

Hillel Yaffe Medical Center

Hadera, Israel

Outcomes

Primary Outcomes

Comparison of fertilization rate

Injected sibling oocytes are incubated in a time-lapse incubator which enables ongoing observation after fertilization and cleavage of each oocyte. The fertilization rates of the ICSI and PICSI methods will be compared.

Time frame: Three years

Comparison of embryo quality

Injected sibling oocytes are incubated in a time-lapse incubator which enables ongoing observation after fertilization and cleavage of each oocyte. The embryo quality of the ICSI and PICSI methods will be compared.

Time frame: Three years

Secondary Outcomes

Implantation rate

Injected sibling oocytes are incubated in a time-lapse incubator which enables ongoing observation after fertilization and cleavage of each oocyte. The implantation rates of the ICSI and PICSI methods will be compared.

Time frame: Three years

Pregnancy rate

Injected sibling oocytes are incubated in a time-lapse incubator which enables ongoing observation after fertilization and cleavage of each oocyte. The pregnancy rates of the ICSI and PICSI methods will be compared.

Time frame: Three years

Miscarriage rate

Injected sibling oocytes are incubated in a time-lapse incubator which enables ongoing observation after fertilization and cleavage of each oocyte. The miscarriage rates of the ICSI and PICSI methods will be compared.

Time frame: Three years

Live birth rate

Injected sibling oocytes are incubated in a time-lapse incubator which enables ongoing observation after fertilization and cleavage of each oocyte. The live birth rates of the ICSI and PICSI methods will be compared.

Central Contacts

Medeia Michaeli, PhD

CONTACT

972-50-6246885 medeia.michaeli@gmail.com

Data from ClinicalTrials.gov

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