Effect of VPro5 Therapy on Clear Aligner Therapy

Inclusion Criteria: 1. Subject must be 18 - 45 years of age 2. Subject is willing and able to comply with all study procedures and sign Informed consent/HIPAA forms 3. Subject must have complete adult dentition (excluding third molars) 4. Subjects must have class I malocclusion or mild class II/III malocclusions 5. Subject is at least one month into aligner treatment. 6. Subject has history of and current healthy oral hygiene (PD is\<4mm, GI\<1, and PI=1) Exclusion Criteria: 1. Subjects who have received periodontal treatment in the previous 6 months 2. Subjects who are taking medication that could affect the level of inflammation, such as chronic antibiotics, phenytoin, cyclosporin, ant-inflammatory drugs, systemic corticosteroids, or calcium channel blockers. 3. Subjects missing adult teeth (except the 3rd molars) or with severe class II or class III malocclusion. 4. Subjects with skeletal class I but extreme dental malocclusion 5. Severe crowding that require extraction 6. More than 4 mm positive overjet and more than 2 mm negative overjet 7. Extreme deep bite (more than 90%); 8. Severe openbite (more than 2 mm) 9. Pregnant women 10. Subjects do not have any systemic diseases effecting bone metabolism 11. Smoking 12. Vulnerable subjects per IRB definitions 13. Subjects with current caries 14. Subjects that require interproximal reduction or attachments during the study period 15. Subjects who are non-compliant regarding aligner wear or VPro5 recommended daily usage