Human Penile Tissue Allotransplantation for Devastating Penile and Concomitant Genital Trauma

Inclusion Criteria: For Recipients 1. Male 2. 18-40 years 3. Irreversible and devastating genitalia damage not amenable to conventional reconstruction. 4. Patent main vessels leading into the remaining penile stump, as confirmed by angiography. 5. Adequate penile stump (\> 2.5cm) to facilitate placement of a tourniquet, debridement of the distal portion and sufficient distal mobilization of the structures requiring anastomosis 6. Eligible for long term standard of care coverage Exclusion Criteria: For Recipients 1. Documented history of: 1. cancer 2. renal impairment 3. hepatic disorders 4. neurologic disorders (sensory or motor function deficits) 5. severe scarring with poor host tissue bed 6. penile resection or implant surgery 7. diabetes 8. hypertension 9. hyperlipidemia 10. coronary artery disease 11. untreated genital cancer 12. HIV, Hepatitis B or C, or any infectious disease 13. erectile dysfunction 14. Peyronie's disease 15. urethral stricture disease 16. balanitis 17. xerotica obliterans 18. pelvic embolization 19. pelvic radiation 20. untreated hypogonadism 21. prior prostate surgery 22. recurrent urinary tract infections (UTIs) 23. nephrolithiasis 24. connective tissue disease or collagen disease 25. lipopolysaccharidosis or amyloidosis 2. Use of 5-alpha-reductase inhibitors 3. External signs, sequelae or positive serology of sexually transmitted disease (including HPV) 4. Active UTI, stones, urethral edema and other pathology that prevents urethral anastomosis 5. Current or past substance abuse 6. Current or past smoker (within past 3 months) 7. Use of any medications known to cause vasoconstriction 8. Psychiatric illness or psychological problems, or deemed unsuitable on psychiatric evaluation 9. Any condition that may prevent transplantation (positive cross match, high panel reactive antibody (PRA), etc.) 10. Uncontrolled bleeding disorder, platelet count \> 50,000, hemophilia or any other inherited coagulopathy or need to routinely receive blood products for bleeding disorders 11. Concurrent participation in any other clinical investigation during the period of this investigation 12. Inability to undergo leukapheresis 13. Inability to participate in all necessary study activities due to physical or mental limitations 14. Inability or unwillingness to return for all required follow-up visits. 15. Inability or unwillingness to sign the patient informed consent document.