The Monocyte Subsets in Obese Patients With and Without Metabolic Syndrome

University Hospital, Ioannina100 enrolled

Overview

Obesity is associated with a chronic low-grade inflammation characterized by macrophage infiltration in adipose tissue that induces insulin resistance and the appearance of metabolic syndrome (MS). The aim of the study was the investigation of whether circulating monocyte subsets are differentially regulated in MS.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Obesity Metabolic Syndrome

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- Exclusion Criteria: Age less than 18 years old, pregnancy, breast feeding, kidney disease, liver disease, gastrointestinal disease, malignancy, any endocrine disorder or metabolic disease, other than obesity or type 2 diabetes mellitus (T2DM), alteration of body weight (BW) by up of 5% of the initial BW during the last 3 months, any state of stress or systemic inflammation and taking any of the following drugs, within 3 weeks prior to the start of the study: hypolipidemic agents, antidiabetics, drugs for weight loss, nonsteroidal antiinflammatory drugs, glucocorticoids.

Locations (1)

University Hospital of Ioannina

Ioannina, Greece

RECRUITING

Outcomes

Primary Outcomes

Monocyte subsets

Absolute blood count of classical (Mon1A), intermediate (Mon2A) and nonclassical (Mon3A) monocyte subsets wil be measured by flow cytometry.

Time frame: Baseline measurement

Data from ClinicalTrials.gov

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