The aim of this study is to evaluate the effect of premedication with pregabalin or gabapentin versus placebo on postoperative shoulder pain after laparoscopic cholecystectomy.
Preoperative premedication with gabapentins reduces preoperative anxiety, stress response to surgical stimuli, decreases anesthetic use. The incidence of postoperative nausea and vomiting appears to be decreased. The other desired effect of gabapentins is the reduction in the intensity of postoperative pain after laparoscopic surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
90
In this group, premedication is performed with 2 capsules of pregabalin 2 hours before anesthetic induction.
In this group, premedication is performed with 2 capsules of gabapentin 2 hours before anesthetic induction.
In this group, no premedication is performed, but patients receive 2 capsules of placebo 2 hours before anesthetic induction.
Sahloul Teaching Hospital
Sousse, Tunisia
Post operative shoulder pain
Primary outcome is the intensity of shoulder pain during the first 48 hours after laparoscopic cholecystectomy using the visual analog scale (VAS).
Time frame: VAS score with rest at 2h, 6h, 12h, 24h and 48 hours after surgery
remifentanil consumption during anesthesia
Remifentanil requirements during anesthesia were calculated (µg/kg/mn)
Time frame: one hour after tracheal tube removal
Post operative sleep quality during the first night
Patient's sleep quality was assessed during the first postoperative night by the Spiegel score.
Time frame: first night after surgery
Post operative nausea and vomiting
The intensity of post operative nausea and vomiting was assessed by a 0 to 3 score (0: no nausea or vomiting, 1: slight mild nausea, 2: moderate nausea, 3: vomiting).
Time frame: 2, 6, 12, 24 and 48 hours after surgery.
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