A Study to Investigate the Safety, Efficacy and Pharmacokinetic Profile of Multiple Doses of QL-007 in Chronic Hepatitis B Patients

Inclusion Criteria: 1. Adult (age 18-65 years inclusive) males or females with chronic HBV (positive for serum hepatitis B surface antigen (HBsAg) or HBV DNA for ≥ 6 months) prior to baseline. 2. Anti-HBV treatment-naive adults; adults who have taken oral anti-HBV nucleoside therapy with the last dose ≥ 4 weeks prior to screening are also eligible. 3. Positive or negative for hepatitis B e antigen (HBeAg). 4. HBV DNA ≥ 20,000 IU/mL. 5. ALT levels could be normal or elevated to \< 10 times upper limit of normal. 6. Creatinine clearance ≥ 70 mL/min. 7. The following laboratory criteria have been met: * Absolute neutrophil count (ANC) ≥ 1.5 x 109/L * Hemoglobin (Hgb) ≥ 8 g/dL * Platelets ≥ 75 x 109/L 8. Negative serum pregnancy test for females of childbearing potential 9. For men and women who are not postmenopausal (ie, ≥ 12 months of non-therapy-induced amenorrhea, confirmed by follicle stimulating hormone (FSH), if not on hormone replacement) or surgically sterile (vasectomy in males or absence of ovaries and/or uterus or tubal ligation in females) agreement to remain abstinent or use a highly effective method of contraception during the treatment period and at least through week 12 after last dose. 10. Participants must have signed an ICF indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study and comply with the study procedures and restrictions. Exclusion Criteria Patients will be excluded from the study if one or more of the following criteria are applicable: 1. Known co-infection with HIV, hepatitis C virus (HCV) or hepatitis D virus (HDV) 2. Presence of autoimmune disorders 3. History of liver disease other than Hepatitis B 4. History of Gilbert's Disease 5. Any sign of decompensated liver disease 6. Known or suspected cirrhosis 7. Evidence of hepatocellular carcinoma 8. Patient has clinically significant, uncontrolled heart disease and/or recent cardiac event (within 6 months), such as: * unstable angina within 6 months prior to screening; * myocardial infarction within 6 months prior to screening; * history of documented congestive heart failure (New York Heart Association functional classification III-IV); * uncontrolled hypertension defined by a systolic blood pressure (SBP) ≥ 160 mm Hg and/or diastolic blood pressure (DBP) ≥ 100 mm Hg, with or without antihypertensive medication; * initiation or adjustment of antihypertensive medication(s) is allowed prior to screening; * ventricular arrhythmias; supraventricular and nodal arrhythmias not controlled with medication; * other cardiac arrhythmia not controlled with medication; * corrected QTc \> 450 msec using Fridericia correction on the screening ECG. 9. Electrolyte abnormalities. 10. Impaired GI function or GI disease that may alter absorption of QL-007. 11. Ongoing GI AEs \> grade 2 (eg, nausea, vomiting, or diarrhea) at screening. 12. Receiving medications that meet one of the following criteria and that cannot be discontinued ≥ 1 week prior to the start of treatment QL 007: * Medication with a known risk of prolonging the QT interval or inducing Torsades de Pointes (see Appendix 3; please refer to https://crediblemeds.org/pdftemp/pdf/CombinedList.pdf * Moderate or strong inhibitors or strong inducers of CYP3A (please refer to http://medicine.iupui.edu/flockhart/table.htm or http://www.druginteractioninfo.org) * Unstable or increasing doses of corticosteroids * Enzyme-inducing anticonvulsive agents * Herbal supplements. 13. Alcohol or substance abuse 14. History of bleeding diathesis 15. Patients with a history of seizures, central nervous system disorders or psychiatric disability thought to be clinically significant in the opinion of the investigator. 16. History of clinically significant gastrointestinal, cardiovascular, endocrine, renal, ocular, pulmonary, psychiatric or neurological disease.