The use of antifibrinolytic agents such as to reduce blood loss in congenital cardiac surgery has been described in many studies
40 patients in each one of the three groups; In control group will receive normal saline, Intravenous Tranexamic acid group received 50 mg / kg intravenousely followed by of 1 mg/kg/hr.for six hours. The topical Tranexamic acid group will have 50 mg / kg of tranexamic poured into the pericoredial cavity. in the first 24 hours we will measure the total blood loss and transfusion requirements. Complate blood picture and coagulation studies will be recorded. the occurrence of re-exploration for excess bleeding, or adverse events.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
120
0.5 ml/kg
1ml/kg/hr. during surgery for six hours
50 mg/kg
Faculty of Medicine
Asyut, Egypt
postoperative blood loss
Blood loss will be measured within first 24 hr.
Time frame: within the first 24 hours
total blood transfusion
ml/kg
Time frame: within the first 24 hours
the interval from protamine to skin closure
the interval from protamine to skin closure
Time frame: within the first 24 hours
the length of ICU stay
by days
Time frame: within the first month
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1mg/kg/hr infusionfor 6 hours
50 mg/kg added to the normal saline 2 ml/kg into the pericardial cavity before sternal closure
2 ml/kg into the pericardial cavity before sternal closure