Benign Liver Optimal Core Study (Tissue Acquisition Comparison in Benign Liver Disease)

Inclusion Criteria: * Subjects that plan to undergo a liver biopsy via EUS to confirm possible underlying liver disease or to determine stage, grade and presence of fibrosis for suspected benign etiology. * History of abnormal LFTs * Documented history of chronic liver disease * Question of underlying liver disease as cause of abnormal imaging or symptoms which may be attributed to liver disorder * Fatty liver disease * Subjects 18 years of age or older * Subject must be able to hold anticoagulants as per institutional standard of care * Subjects must be deemed physically able to undergo anesthesia. This includes either Monitored Anesthesia Care (MAC) or general anesthesia. * Subjects (or the subjects Legally Authorized Representative \[LAR\]) that have agreed to participate in the study and have signed Informed Consent * Women of child bearing potential who are not pregnant as proven by a negative pregnancy test may be included. Exclusion Criteria * Subjects that are unable to tolerate anesthesia for the procedure * Subjects 17 or under * Subjects whose anticoagulants cannot be held * Subjects who cannot have or refuse EUS guided procedure * Subjects who are pregnant * INR \>1.5 * Platelets 50,000 or less * Subjects requiring control of bleeding on initial upper endoscopy * Subjects requiring endoscopic mucosal resection * Subjects with large volume ascites * Subjects requiring pancreatic biopsies