Cardiac Function and Metabolism in Young Adults Born Premature (PET-MRI)

University of Wisconsin, Madison52 enrolled

Overview

The purpose of this research is to determine the effect of premature birth on later heart function and metabolism.

The purpose of this study is to determine the effects of premature birth on cardiac function, cardiac metabolism, and oxidative stress in a cohort of young adults born prematurely using cardiac positron emission tomography/magnetic resonance imaging and mitochondrial respiration studies.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Infant,Premature

Interventions

Pulmonary Function TestingPROCEDURE

Subjects will undergo Spirometry and Plethysmography

ElectrocardiogramPROCEDURE

Subjects will undergo an electrocardiogram to ensure sinus rhythm

Positron Emission TomographyPROCEDURE

Subjects will undergo positron emission tomography to detect images of the heart

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * National Lung Project Cohort only- birth weight \<1500g and a gestational age \<36 weeks * Adults born preterm (Non-National Lung Project) only- gestational age ≤32 weeks OR birth weight ≤ 3lbs 5oz * Healthy Controls only- No personal history of known cardiovascular or pulmonary disease Exclusion Criteria: * Metabolic Disorders that would affect Fludeoxyglucose uptake * Contraindications to positron emission tomography and/or magnetic resonance imaging * Pregnancy, if a female of child-bearing potential * A personal history of Type I or Type II diabetes

Locations (1)

UW Madison

Madison, Wisconsin, United States

Outcomes

Primary Outcomes

Cardiac Glucose Uptake During Normoxic Rest (µg/Min)

Cardiac glucose uptake will be measured via 18F-fluorodeoxyglucose (FDG) PET-MRI.

Time frame: Visit 1 (1 day)

Change in Glucose Uptake From Normoxia to Hypoxia (µg/Min)

Cardiac glucose uptake will be measured via 18F-fluorodeoxyglucose (FDG) PET-MRI.

Time frame: Visit 1 (1 day)

Data from ClinicalTrials.gov

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