Study of Chidamide as a Single-agent Treatment for Patients With Relapse or Refractory B-NHL

Inclusion Criteria: 1. Diagnosed as B-cell Non-Hodgkin's Lymphoma (NHL) according to "2008 WHO classification of tumors of haematopoietic and lymphoid tissues", including Diffuse Large B-Cell Lymphoma (DLBCL), Mantle Cell Lymphoma (MCL), transformed indolent lymphoma (TL), and other subtypes that investigators consider to be appropriate to be enrolled; 2. Patients achieved CR or PR in previous cytotoxic chemotherapy, and relapsed later than 6 months after remission; 3. Patients with DLBCL, FL grade3, MALT, LPL and SLL received at least two chemotherapy regimens, and Patients with FL grade1-2 received at least three chemotherapy regimens; 4. At least one measurable lesion with a longest diameter \>1.5cm or a short axis \>1.0cm; 5. Age18-75 years; 6. ECOG performance status 0-2; 7. Life expectancy no less than 3 months; 8. Functions within 7 days prior to enrollment: Blood routine test: Hb ≥ 80g/L, absolute neutrophil count ≥1.5 × 109/L, platelet ≥60 × 109/L; Total bilirubin ≤ 1.5 times of normal maximum, ALT/AST≤ 2.5 times of normal maximum, for patients with liver metastasis ALT/AST≤ 5 times of normal maximum; serum creatinin≤1.5 times of normal maximum or CCr≥ 60ml/min; 9. LVEF ≥ 50% by echocardiography; 10. Contraception during and 4 weeks after the study for patients at child bearing age; 11. Patients have signed the Informed Consent Form. Exclusion Criteria: 1. Patients received Chidamide treatment within 6 months prior to enrollment; 2. Patients with Burkitt Lymphoma, B-lymphoblastic lymphoma, central nervous system lymphoma and HIV-Associated Lymphoma; 3. Patients with a "currently active" second malignancy; 4. Patients not recovered from non-hematologic toxicities within 4 weeks prior to enrollment due to chemotherapy, radiation and immunotherapy; 5. Patients receiving or received corticosteroids within 2 weeks prior to enrollment; 6. Patients with cumulative life time dose of Doxorubicin \> 450mg/m2; 7. Patients who have been treated with any investigational drug within 4 weeks prior to enrollment; 8. Women during pregnancy or lactation; 9. Patients with active infection, medical conditions, or mental disorders; 10. Patients with active infection of HBV, HCV or HIV; 11. Congestive heart failure (NYHA grade III/IV), myocardial infarction within 6 months, QTc elongation with clinical significance (≥480ms), hypertension BP≥150/100 mmHg and symptomatic coronary heart disease that require treatment; 12. Patients with drug abuse, long term alcoholism that may impact the results of the trial; 13. Non-appropriate patients for the trial according to the judgment of the investigators.