Microbial Colonization and Change of Chronic Keratinized Hand Eczema After Using Halometasone Triclosan

Inclusion Criteria: * Age ≥ 18 years * Chronic Keratinized hand eczema for at least 3 months * The affected area is greater than 30% * Overall assessment of the severity of the disease(IGA)≥3 OR HEES≥13 * No obvious incentive .Who have read the instructions of the subject, agreed to and signed written informed consent, and have been able to provide a personal medical history. Exclusion Criteria: * Pregnancy, breast feeding * Severe liver and kidney disease, blood system disease, autoimmune disease, chronic severe infection, diabetes, mental illness, drug use, alcohol abuse, etc * Malignant neoplasms or other serious maladies that may affect the correct assessment of efficacy * Topical corticosteroid was suspended for less than 2 weeks;The system used corticosteroids and other immunosuppressive agents (thunder vine and other drugs) which were suspended for less than four weeks * Eczema of the facial and skin creases * Atopic dermatitis, contact dermatitis, blister hand eczema, contact urticaria, discoid eczema * participated in other clinical trials within 3 months. * Known sensitivity to Halometasone Triclosan * failure to follow the prescribed medication or the incomplete record of the test process which will affect the curative effect judgment * Other reasons why researchers think they should not be included