Obstetric Anesthesia and Analgesia and Multiple Sclerosis

Brno University Hospital70 enrolled

Overview

Aim of the retrospective study was to evaluate the influence of the labour on the clinical course of the parturients with MS in selected 6 month follow-up interval and to evaluate to possible influence of the different anesthesia/analgesia types on the course of MS.

The role of anesthesia in multiple sclerosis (MS) progression remains unclear in spite of few foreign studies. The most frequently afflicted patients by MS are women of childbearing age and influence of anesthesia or obstetric epidural analgesia has only not been investigated in Czech Republic. The study aims to retrospectively compare the further course of the disease of MS in patients who labor between 2004 and 2013 in University Hospital Brno either by caesarean section or vaginally with epidural analgesia , with patients who gave birth spontaneously without anesthesia.The aim of the study was to evaluate the influence of the labour on the clinical course of MS and further evaluate the possible influence of the type of anesthesia/analgesia in the peripartal period on the MS progression.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Multiple Sclerosis

Interventions

Data searchOTHER

Patients data were searched for the patients with MS, who laboured in tertiary perinatology center in the study period

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Parturients with multiple sclerosis * Possible follow up - neurologic examination available after 10 month from delivery Exclusion Criteria: * probable or no multiple sclerosis at time of labor * unknown neurology history * unknown data on neurology outcome 6 months after labour * Incomplete data * Follow-up not possible

Locations (1)

Brno University Hospital

Brno, Czechia, 62500, Czechia, Czechia

Outcomes

Primary Outcomes

Multiple sclerosis decompensation/progression at 3rd month

Relapse occurence from labour to 3 months, after delivery was recorded. A relapse was defined as the appearance or worsening of symptoms of neurologic dysfunction lasting more than 24 hours, new lesions on MRI or need of reinforcement in treatment. For disease state after delivery we used dichotomic approach: relapse (at least one) or no relapses.

Time frame: 3 months after labour

Multiple sclerosis decompensation/progression

Relapse occurence from labour to 6 months after delivery

Time frame: 3 months after labour

Secondary Outcomes

MS progression and the type of anesthetic method

MS progression comparison due to the type of anethesia

Time frame: 6 months after labour

Data from ClinicalTrials.gov

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