Glycemic Index of Table Grape Varietals

University of California, Davis14 enrolled

Overview

Investigate the postprandial glycemic responses of healthy individuals when consuming commercially available table grape varietals or grape juice, compared to a standard amount of glucose.

The study aims to investigate the postprandial glycemic responses of healthy individuals when consuming commercially available table grape varietals, compared to a standard amount of glucose. The study also aims to evaluate a new grape varietal, compared to other common table grapes, with regard to glycemic index and metabolic response related to inflammation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Healthy

Interventions

Milano grapesOTHER

Milano grapes to test post-prandial glycemic response

Table grapesOTHER

Table grapes to test post-prandial glycemic response

Grape juiceOTHER

Grape juice to test post-prandial glycemic response

Eligibility

Sex: ALLMin age: 21 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy men and women * 21-75 years of age * BMI range 20-35 Exclusion Criteria: * adults unable to consent, individuals who are not yet adults (children), pregnant women, and prisoners. * BMI of \>35 or morbid obesity. * Diagnosed type 1 or 2 diabetes, fasting blood glucose of \>125 mg/dl, or reported use of medications or supplements known to affect glucose metabolism (insulin, sulfonylureas, metformin, glucosidase inhibitors, thiazolidinedione, insulin sensitizers, GLP-1 mimetics). * Medications known to affect gastrointestinal motility (prokinetic agents such as reglan). * Renal, liver, pancreatic or cardiovascular disease, uncontrolled hypertension of \> 160/90, inflammatory bowel disease, disorders of esophageal and gastrointestinal motility, previous gastric resection or restriction procedures, autoimmune or immunologic disorders, anemia, breastfeeding women * Food allergy to grapes, or inability to tolerate gluten (celiac disease). * Poor venous access. * Smoking, illicit drug use, consuming \>7 alcoholic drinks per week. * Weight gain or loss of \> 5 kg within the prior 6 months. * Unwillingness to adhere to study protocol.

Locations (1)

University of California Davis (Academic Surge, Ragle Human Nutrition Research Facility)

Davis, California, United States

Outcomes

Primary Outcomes

Glycemic Index

The post-prandial glucose and insulin responses in healthy individuals to glucose containing foods or beverages.

Time frame: 3 hours

Data from ClinicalTrials.gov

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