Efficacy of Intra-articular Neostigmine Versus Ketamine for Postoperative Analgesia in Arthroscopic Knee Surgery

Assiut University100 enrolled

Overview

To compare the efficacy of intra-articular administration of neostigmine versus ketamine as adjuvant analgesics after knee arthroscopy.

Arthroscopic knee surgery is commonly performed as an outpatient procedure and is often associated with postoperative pain. Intraarticular (IA) local anesthetics (LA) are often used for prevention of pain after arthroscopic knee surgery; however, the degree of postoperative pain varies. In an effort to find the ideal regime for sufficient, long-lasting postoperative analgesia, many different drugs, including opioids, nonsteroidal anti-inflammatory drugs, ketamine, clonidine, and neostigmine, have been added to the IA LAs The investigators designed this study to compare the efficacy of intra-articular administration of neostigmine versus ketamine as adjuvant analgesics after knee arthroscopy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

100

Conditions

Postoperative Pain

Interventions

NeostigmineDRUG

patient receive 0.5mg/dose neostigmine +18ml 0.25%bupivacaine in a total volume of 20 ml.

ketamineDRUG

patient receive 0.5 mg/kg ketamine+18ml 0.25%bupivacaine in a total volume of 20 ml.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * One hundred patients aged above 18-50 years (ASA I or II) scheduled for elective arthroscopic knee surgery under intrathecal anaesthesia will be enrolled in our study. Exclusion Criteria: * Absolute or relative contraindications for intrathecal anaesthesia, * Allergy for the studied drugs. * Patients having history of cardiovascular, cerebrovascular, and respiratory diseases, * Patients receiving chronic pain treatment or hypertension treated with α methyldopa, clonidine or β adrenergic blockers were excluded from the study.

Locations (1)

Assiut university hospitals

Asyut, Assiut Governorate, Egypt

Outcomes

Primary Outcomes

postoperative analgesic consumption

assessment of each patient on his bed at inpatient ward every 4 hours over a 36-hour period

Time frame: 36 hours postoperative the total consumption of analgesics in the first 36h postoperative

Secondary Outcomes

Postoperative visual analogue pain scale (VAS)

assessment of each patient on his bed at inpatient ward every 4 hours over a 36-hour period

Time frame: 36 hours postoperative

Data from ClinicalTrials.gov

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