This study aims to compare two different protocols commonly used in the management of post thyroidectomy hypoparathyroidism : PTH based calcium repletion and empiric repletion. The investigators aim to compare the quality of life associated with these two protocols in a randomized trial.
Enrolled patients will be randomized in two treatment groups. In group 1, all patients will receive calcium carbonate and calcitriol in the post-operative period, with standardized weaning. In group 2, patients will be prescribed calcium carbonate and calcitriol only if their post-operative PTH dosage is 25% or less of the pre-operative dosage, or if post-operative PTH is inferior to 15. The Short-Form 36 (SF-36) questionnaire (French canadian version) will be used to assess quality of life pre-operatively and at post-op week 1 and 4. Symptoms of hypocalcemia and adverse effects of calcium carbonate and calcitriol will be monitored at week 1 and 4.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
120
Empiric calcium carbonate and calcitriol repletion
PTH based treatment
CHU de Quebec
Québec, Quebec, Canada
RECRUITINGChange from baseline quality of life at 1 and 4 weeks
Short Form 36 (SF-36) questionnaire
Time frame: Pre-op, 1 week post-op and 4 weeks post-op
Occurence and change in pharmacologic adverse effects of calcium carbonate and calcitriol
A questionnaire about the adverse effects of calcium carbonate and calcitriol will be completed at post-op week 1 and 4
Time frame: 1 week post-op, 4 weeks post-op
Occurence and change in symptoms of hypocalcemia
A questionnaire about symptoms of hypocalcemia will be completed at post-op week 1 and 4.
Time frame: 1 week post-op, 4 weeks post-op
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