This study investigates electrical acupoint stimulation (EAS) administered in peri-operation for improving postoperative recovery in elder patients, who accept knee arthroplasty. the surgery cause to change of stress response, which might be associated with postoperative recovery of patient Totally, three groups are created, 1/3 participants receive transcutaneous electrical acupoint stimulation, 1/3 participants receive electroacupuncture, the rest 1/3 will use sham transcutaneous electrical acupoint stimulation.
Theoretically, the application of electrical acupoint stimulation (EAS) base on the theory of traditional Chinese medicine. It deems that a surgery might consume Qi, then cause to imbalance of Qi and Blood, especially in elder patients. Besides, surgery lead to change of stress response (hormones). The EAS administration intra-operatively perhaps be beneficial to recovery of patients, reduce the incidence of postoperative complications. The main possible mechanism was stress response regulation. The hypothesis is that the EAS improve postoperative recovery of patient through regulating stress response.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
90
The intervention will be administered by electrical acupoint machine, the brand is Great Wall.
The intervention will be administered by electrical acupoint machine, the brand is Great Wall.
The intervention will be administered by transcutaneous electrical acupoint machine, even no truly actualized.
Affiliated hospital of shandong university of traditional chinese medicine
Ji'nan, Shandong, China
The postoperative recovery
Record the postoperative recovery after surgery through quality of recovery-40 questionnaire.
Time frame: 7 days
The adverse event
Record all the adverse events appeared during the entire trail, which might cause to skin rash, allergic reaction, et al.
Time frame: 7 days
The level of stress response
Assess the level of preoperative stress response at 1, 3, 7 days after operation. It mainly include Adrenocorticotropic Hormone (ACTH), Cortisol (COR), Adrenaline (E), norepinephrine (NE). All measures unit is pg/ml.
Time frame: up to 7 days
Postoperative complications
Record the incidence of any postoperative complications during 7 days
Time frame: 7 days
The level of inflammatory response by TNF-a, IL-1, IL-6, IL-10
Assess the level of perioperative inflammatory response at 1, 3, 7 days after operation. It mainly include Tumor Necrosis Factor-a (TNF-a), Interleukins-1 (IL-1), Interleukins-6 (IL-6), Interleukins-10 (IL-10). All measures unit is ng/ml.
Time frame: up to 7 days
The level of inflammatory response by C-reactive protein
Assess the level of perioperative inflammatory response at 1, 3, 7 days after operation through C-reactive protein. the unit is mg/L.
Time frame: up to 7 days
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