Haploidentical and Mismatched Unrelated Donors Hematopoietic Stem Cell Transplant

Inclusion Criteria: * With a hematological malignancy requiring a HSCT and at least in partial response ie a) Acute Leukemia in complete remission, b) Myelodysplastic syndromes with less than 20% marrow, c) Myeloproliferative syndromes with less than 20% bone marrow blasts, d) Non Hodgkin Lymphoma (NHL), Hodgkin's disease, chronic lymphocytic leukemia at least in partial response, e) Myeloma at least in partial response. * Without HLA matched related or unrelated donor * Identification of a possible HLA-9/10 MMUD and a possible haplo-identical donor. * Having read and understood the information letter and signed the informed consent * With health insurance coverage Exclusion Criteria: * Organic or psychiatric disease, non related to the hematological malignancy, contraindicating the transplant. * Performance Scale by the Eastern Cooperative Oncology Group (ECOG)\> 2 * Severe uncontrolled infection * Cardiac contraindication of post-transplant Cy (coronary insufficiency, ejection ventricular fraction \<50%) * Aspartate transaminase (AST) and alanine transaminase (ALT) \> 2.5 N, creatinine \> 150 mmol/L (except if related to malignancy) * Previous active cancer in the last two years, except basal cell skin cancer and in situ carcinoma of the cervix * Childbearing age woman refusing contraception * Patients who did not accept the follow-up planned by the protocol * Positive serology for HIV or Human T-Lymphotropic Virus (HTLV)-1, 2, or active viral infection by the Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) * Pregnant woman (positive β-HCG) or during lactation * Adult patient on guardianship, or safeguard justice