Prospective cohort study to test the hypothesis that patients identified with severe aortic stenosis are under-diagnosed and under-treated. Such patients shall be identified by auscultation or target echocardiography during flu vaccination. The hypothesis is that this will increase detection of aortic stenosis in the community.
The design plans for two study phases: 1. Feasibility study: screening by auscultation and target echocardiography during flu vaccination in a single practice in Birmingham; 2. Screening study: multi-centre screening by auscultation or target echocardiography in geographically diverse general practices across the United Kingdom. In each phase, the patient will be identified by auscultation and target echocardiography. Management and onward referral will be at the clinical discretion of the GP. Results of clinical review, investigation, follow-up and management will be recorded at 3 months from that date.
Study Type
OBSERVATIONAL
Enrollment
167
Whaddon Medical Center
Milton Keynes, Buckinghamshire, United Kingdom
Swanswell Medical Centre
Birmingham, United Kingdom
prevalence of aortic stenosis
Determination of the prevalence of aortic stenosis detected on screening performed during flu vaccination.
Time frame: From date of examination until follow-up after three months
comparison of detection rate of aortic stenosis
Comparison of detection rates of aortic stenosis using target auscultation vs detection by target 2D echocardiography.
Time frame: From date of examination until follow-up after three months
Evaluation of qualitative estimation of calcium burden on 2D echocardiography as a marker of AS severity
Method evaluation
Time frame: three months
Calculation of costs in screening with auscultation versus target 2DE in screening for AS to inform future cost-efficacy studies of screening for AS.
Cost evaluation
Time frame: three months
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