Acellular Dermal Matrix Allograft Versus Free Gingival Graft

University of Sao Paulo25 enrolled

Overview

The present split-mouth controlled randomized clinical trial aimed to evaluate clinical and histological results of acellular dermal matrix allograft (ADM) compared to autogenous free gingival graft (FGG)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Gingiva Atrophy Gingivitis

Interventions

ControlPROCEDURE

Free epithelized gingival graft, harvested from palate, was grafted in a site with lack of keratinized gingiva

Acellular Dermal MatrixDEVICE

Acellular Dermal Matrix was grafted in a site with lack of keratinized gingiva, in substitution of an autogenous graft from patient palate

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * absence or deficiency of keratinized tissue (\< 1mm) in two homologous contralateral sites of inferior premolars * Miller Class I or II gingival recession * Absence of radiographic bone loss * Vital tooth or with adequate endodontic treatment * Root surfaces without caries * Good oral hygiene (plaque index \< 20%) Exclusion Criteria: * Allergic to penicillin * Presenting systemic disease that impede surgical procedure * Smokers * Pregnancy * Intake of calcium channel blockers that cause gingival augmentation

Locations (1)

Bauru School of Dentistry

Bauru, São Paulo, Brazil

Outcomes

Primary Outcomes

keratinized tissue width

Distance from gingival margin to mucogingival junction, measured with a periodontal probe in mm. Ideal if mucosa width is \> 5mm.

Time frame: 18 years

Secondary Outcomes

Probing depth

Distance from gingival margin to bottom of gingival sulcus, measured with a periodontal probe. Ideal if \< 2mm.

Time frame: 18 years

Attachment level

Distance from cemento-enamel junction to bottom of gingival sulcus, measured with a periodontal probe. Ideal if \< 2mm.

Time frame: 18 years

Recession depth

Distance from cemento-enamel junction to gingival margin, measured with a periodontal probe. Ideal if = 0mm.

Time frame: 18 years

Data from ClinicalTrials.gov

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