The study aimed to determine the thrombotic effects of YSS compared with salmon among healthy overweight subjects. It hypothesized that YSS may result significant, favorable thrombotic effects and the effects may be similar with salmon.
The project was a randomized, two-period, crossover trial with 8-week treatment periods and 8-week washout period. A total of 50 healthy overweight adults were recruited among staff and students in UPM. All the subjects were randomized into two groups. Each group was served with either cooked YSS (\~265 g/ day) or salmon (\~246 g/day) thrice per week. Blood and urine samples were collected for laboratory assessment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
50
Changes in hemostatic status assessed by immunoassay method
Hemostatic markers including vWF-A2 and CD62b (p-selectin) in pg/mL are evaluated.
Time frame: 8 weeks
Changes in lipid and glucose profiles analysed by medical diagnostic laboratory
Total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol, and fasting blood glucose in mmol/L are evaluated.
Time frame: 8 weeks
Changes in liver enzymes analysed by medical diagnostic laboratory
Serum levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline Phosphatase (ALP) and gamma glutamyl transferase (GGT) in IU/L are determined.
Time frame: 8 weeks
Changes in renal function analysed by medical diagnostic laboratory
Serum levels of creatinine, urea, and electrolytes (sodium, potassium, and chloride) in mmol/L are determined.
Time frame: 8 weeks
Changes in body mass index (BMI)
Weight and height are combined to report BMI in kg/m\^2
Time frame: 8 weeks
Changes in blood pressure
Seated systolic and diastolic blood pressures are taken in mmHg.
Time frame: 8 weeks
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