Fibrin Sealant in Esophageal Surgery

Amsterdam UMC, location VUmc15 enrolled

Overview

Anastomotic leakage remains a major complication after esophageal surgery. Amongst other preventive measures, fibrin sealant is a promising adjunct to conventional anastomotic techniques. The investigators aimed to investigate feasibility of additional sealing by means of autologous fibrin sealant of the esophageal anastomosis.

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Anastomotic Leak

Interventions

Autologous activated fibrin sealantDEVICE

Application of fibrin sealant

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 18 - 90 years * Scheduled to undergo elective minimal invasive esophageal surgery with thoracic or cervical anastomosis (i.e. Ivor Lewis, Orringer or McKeown esophagectomy). * physical status (American Society of Anesthesiologists) of 3 or lower Exclusion Criteria: * Other malignancies * Previous esophageal surgery were excluded

Outcomes

Primary Outcomes

Anastomotic leakage

Time frame: 30-day morbidity

Data from ClinicalTrials.gov

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