Osteoporosis after gastrectomy, which is characterized by both the loss of bone mass and the deterioration of bone architecture, is a serious complication in the long course after gastrectomy. The aim of the present study was to evaluate osteoporosis by using high-resolution peripheral quantitative computed tomography (HR-pQCT) in the long course after gastrectomy. In total gastrectomy and distal gastrectomy groups, at least 5 years should have elapsed since gastrectomy.
The patients after gastrectomy loss appetite and decrease the weight. Total gastrectomy especially cause severe sarcopenia and metabolic change. Osteoporosis after gastrectomy, which is characterized by both the loss of bone mass and the deterioration of bone architecture, is a serious complication in the long course after gastrectomy. The primary tools for assessing volumetric density and bone structure are quantitative computed tomography (QCT) and more recently, high-resolution peripheral quantitative computed tomography (HR-pQCT). However the validation of osteoporosis with HR-pQCT in the long course after gastrectomy remain elusive. The aim of the present study was to evaluate osteoporosis by using HR-pQCT in the long course after gastrectomy. In total gastrectomy and distal gastrectomy groups, at least 5 years should have elapsed since gastrectomy.
Study Type
OBSERVATIONAL
Enrollment
114
Distal gastrectomy, Total gastrectomy
Nagasaki University Hospital
Nagasaki, Japan
RECRUITINGComparing bone microstructure in control, DG, and TG groups
volumetric bone mineral density
Time frame: day1
Comparing bone microstructure with sarcopenia
Correlation between bone mineral density in HR-pQCT and cross-sectional area of the abdominal psoas major muscle
Time frame: day1
Comparing bone microstructure with serum biomarkers of osteoporosis
Correlation between bone mineral density in HR-pQCT and biomarkers (25-hydroxyvitaminD, calcium, iPTH, P1NP, ICTP, TRACP5b)
Time frame: day1
Comparing bone microstructure with dual-energy X-ray absorptiometry
Correlation of bone mineral density between HR-pQCT and DXA
Time frame: day1
Comparing bone microstructure with quality of life (QOL-C30)
Patients will be asked to complete a short debriefing questionnaire covering questions (QOL-C30)
Time frame: day1
Comparing bone microstructure with quality of life (BDHQ)
Patients will be asked to complete a short debriefing questionnaire covering questions ( BDHQ)
Time frame: day1
Comparing bone microstructure with quality of life (FRAX)
Patients will be asked to complete a short debriefing questionnaire covering questions (FRAX)
Time frame: day1
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