This study hypothesizes that early-onset neonatal Infections are related to premature rupture of membrane (PROM) and that early intervention can improve the prognosis of newborns. The objective of this study is to analyze the correlation between PROM and early-onset neonatal infections and to assess the prognosis of newborns. A cohort study is designed to implement the study. The subjects of study group are pregnant women who are diagnosed as PROM or chorioamnionitis and whose gestational age is ≥ 24 weeks. The subjects of control group are pregnant women without PROM and chorioamnionitis. Control group and research group are paired at 1: 1 ratio. The main contents of the study include three aspects. (1) The correlation between PROM and chorioamnionitis. (2) The correlation between PROM and early-onset neonatal infections. (3) The pathogenesis of intrauterine infection and neonatal infection.
Study Type
OBSERVATIONAL
Enrollment
15,926
Chengdu Women's and Children's Central Hospital
Chengdu, China
Second Hospital of Jilin University
Jilin City, China
Nanjing Maternity and Child Health Care Hospital
Nanjing, China
Shenzhen Bao'an Maternal and Child Health Hospital
Shenzhen, China
Shenzhen Maternity & Child Healthcare Hospital
Shenzhen, China
Northwest Women's and Children's Hospital
Xi'an, China
the incidence of early-onset neonatal infections
The incidence of early-onset neonatal infections will be compared between study group and control group.
Time frame: 7 days after birth
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