Tear Concentrations and Pharmacokinetics of Azithromycin Eye Drops in Healthy Volunteers

Inclusion Criteria: * 18 to 45 years old, male or female; * BMI in the range of 19 to 24; * eyes corrected visual acuity should be ≥ 1.0, intraocular pressure, slit lamp and fundus examination were normal, tear secretion function is normal; * Good compliance and voluntarily signed consent. Exclusion Criteria: * Have eye disease or systemic disease; * physical examination, laboratory tests, ECG and chest X-ray examination abnormalities and has clinical significance; * HBsAg, anti-HCV, anti-HIV and TPPA positive; * those who used eye drops two weeks before the test and who used any dosage form of azithromycin; * known to azithromycin or macrolide-related varieties of allergies or serious adverse reactions; * need to wear contact lenses during the test; * history of internal surgery or laser surgery history; * participated in other drug clinical trials in the past three months; * pregnant women and lactating women, or in the growth period without taking effective contraceptive measures, menstrual period women; * mental illness or alcohol, history of drug abuse or inability to collaborate; * Any other circumstances that the investigators consider are unfit to participate in this study.