Effects of the Interventions Using Multiple Sensory Integrations on Preterm Infants' Stress-Related Outcomes

National Defense Medical Center, Taiwan150 enrolled

Overview

Frequent pain and distress may affect infants' brain and neural development, and highlight the need for relieve pain interventions. Peripheral venous puncture procedures are an important source of preterm infants' pain and distress. Brain development is mainly created by infant sensory experience. It becomes important, therefore, to relieve preterm infants' pain and distress using multiple sensory integrations during peripheral venous puncture procedures.The proposed 2-year study has specific aim: to compare the effects of different combination of sensory integrations on preterm infants' pain and distress before, during, and after peripheral venous puncture procedures.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

150

Conditions

Preterm Infants Pain

Interventions

Eligibility

Sex: ALLMin age: 3 DaysMax age: 28 DaysHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Gestational age (GA) 28-37 weeks * Post-menstrual age (PMA) 29-38 weeks * Postnatal age 3-28 days * Sable condition (NTISSscore ≦ 22) * Apgar scores≧7 at 5 minutes after birth Exclusion Criteria: * Neurologic impairment * Congenital anomalies * Surgery * Severe growth restriction at birth * Severe medical conditions requiring treatments

Outcomes

Primary Outcomes

Preterm infants' pain

Premature Infant Pain Profile-Revised (PIPP-R) for pain, A score \<7 suggests no or little pain, 7-12 mild to moderate pain and scores \>12 indicate moderate to severe pain.