Translational Approaches to Septic Cardiomyopathy

Samuel Brown24 enrolled

Overview

This translational study will assess the association between septic cardiomyopathy (measured via left ventricular global longitudinal strain) and (a) inflammatory cytokine profiles, and (b) the behavior of cardiomyocytes derived from inducible pluripotent stem cells.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cardiomyopathies Sepsis Septic Shock

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

INCLUSION CRITERIA At least 18 years of age Admitted to the ICU SEPSIS PATIENTS: Sepsis patients must have: 1. Suspected or confirmed infection AND 2. Organ dysfunction as defined by a SOFA \>= 2 above baseline (if no baseline data available, SOFA assumed to be 0) OR SEPTIC SHOCK PATIENTS: AFTER INFUSION OF 20ML/KG CRYSTALLOID OR EQUIVALENT, septic shock patients must have: 1. Suspected or confirmed infection AND 2. Lactate \> 2 mmol/L AND 3. Receiving vasopressors EXCLUSION CRITERIA Known pregnancy Primary diagnosis of acute coronary syndrome Known preexisting heart disease Known severe valvular disease (regurgitation or stenosis) Major cardiac dysrhythmia such as: * Ventricular tachycardia (V-tach) * Ventricular Fibrillation (V-fib) * Third degree heart block (complete hear block or complete AV block)

Locations (2)

Stanford University

Stanford, California, United States

Intermoutain Medical Center

Murray, Utah, United States

Outcomes

Primary Outcomes

Correlation of cytokine profile with left ventricular global longitudinal strain

This outcome assesses the correlation between inflammatory cytokines (summarized via PCA) and septic cardiomyopathy, as assessed by left ventricular global longitudinal strain.

Time frame: Day 1

Secondary Outcomes

Adrenergic susceptibility of pluripotent stem cell-derived cardiomyocytes

This is a laboratory-based outcome, using pluripotent stem cell-derived cardiomyocytes, with exposure to adrenergic agonists and antagonists in vitro

Time frame: Day 1

Data from ClinicalTrials.gov

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