Study on the Efficacy of Alprostadil Injection in Patients With Acute Ischemic Stroke

Inclusion Criteria: 1. ischemic stroke diagnosed by CT or MRI 2. Age: 18-75 years 3. Pre-stroke mRS score is 0-1 4. within 72 hours symptoms onset 5. 4 ≤ NIHSS \<20 6. Patient is willing to participate voluntarily and to sign a written patient informed consent Exclusion Criteria: 1. intracranial tumors, encephalitis or lesions diagnosed by CT or MRI 2. patients with thrombolytic therapy 3. low platelet , blood system diseases or other bleeding tendency 4. suspected subarachnoid hemorrhage or aortic dissection coma 5. atrial fibrillation, myocardial infarction, heart valve disease, infective endocarditis, heart rate \<50 beats / min 6. ALT or AST continued to rise more than 3 times the upper limit of normal creatinine clearance rate\<30ml/min 7. Dementia and mental illness 8. Patient who is participating in other trials or has been participated in other trials in recent 3 months