Uterus Transplantation From a Multi-organ Donor

University Hospital, Ghent20 enrolled

Overview

Uterus transplantation: screening, in vitro fertilization \[IVF\] treatment to be able to freeze embryos, uterus transplantation, pregnancy and afterwards removal of the uterus.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Infertility, Female Mayer Rokitansky Kuster Hauser Syndrome

Interventions

uterus transplantationPROCEDURE

transplantation of a uterus from a deceased donor

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 38 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Female with Maier-Rokitansky-Kuster-Hauser syndrome * Mucosal neovagina of at least 7 cm * In a stable relationship for at least 1 year * Child wish * Good renal function (and presence of both kidneys) * Psychologically stable and compliant * At least 8 frozen embryos after IVF/intracytoplasmic sperm injection \[ICSI\] * Living in Belgium and a good health insurance * Willing and able to provide informed consent Exclusion Criteria: * Major pelvic surgery * Major chronic illnesses * Other risk factors or malignancies * BMI \> 30

Locations (1)

Ghent University Hospital - Women's Clinic

Ghent, Belgium

RECRUITING

Outcomes

Primary Outcomes

Survival of the uterus 1 year after transplantation

Time frame: 1 year after uterus transplantation

Complications after uterus transplantation

Time frame: As long as the uterus remains in situ (the uterus will be removed within one year after delivery)

Ongoing pregnancy rate

Time frame: 4 weeks after embryo transfer

Take home baby rate

Time frame: 9 months after embryo transfer

Central Contacts

Steven Weyers, MD, PhD

CONTACT

+3293325446 steven.weyers@uzgent.be

Sara Somers, MSc

CONTACT

+3293323757 Sara.Somers@uzgent.be

Data from ClinicalTrials.gov

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