Tailored PCA Based on Preoperative Pain Sensitivity

Seoul National University Hospital118 enrolled

Overview

Opioids via intravenous patient-controlled analgesia (IV PCA) are widely used for postoperative pain control. However, effective pain control with minimized side effects of analgesic agents is still challenging. Several studies reported that preoperative pain sensitivity measured by quantitative sensory test could predict postoperative pain. Therefore, the investigators planned this trial to evaluate the effectiveness of tailored patient-controlled analgesia based on preoperative pain sensitivity measured by pressure pain threshold in patients undergoing gynecological surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

118

Conditions

Analgesia, Patient-Controlled

Interventions

Tailored regimen of IV PCA according to pain sensitivityOTHER

In tailored group, fentanyl dosage in IV PCA will be determined according to preoperative pain sensitivity. In control, group, fentanyl dosage in IV PCA will be determined without consideration of patient's pain sensitivity.

Regimen of IV PCA without considering pain sensitivityOTHER

In control group, regimen of IV PCA will be determined without consideration about patient's pain sensitivity.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients scheduled to undergo elective gynecological surgery under general anesthesia * patients scheduled to use IV PCA for postoperative analgesia * patients with American Society of Anesthesiologists (ASA) physical status classification I, II, III Exclusion Criteria: * contraindication to fentanyl use * inability to communication * age less than 18 years, or more than 80 years * body weight less than 40kg, or more than 90kg * morbid cardiovascular disease * pregnancy

Locations (1)

Seoul National University Hospital

Seoul, South Korea