Turmeric as Treatment in Epilepsy

NYU Langone Health

Overview

This is a single center open-label pilot clinical trial of patients 1-70 years of age with greater than 6 seizures per month diagnosed with Dravet Syndrome, Lennox-Gastaut Syndrome, Tuberous Sclerosis, or focal seizures. Twenty patients will be enrolled and treated with a stable dose of orally administered turmeric oil daily for 3 months. Patients and caregivers will be asked to keep a seizure diary logging all clinical events during the course of the study. Serum comprehensive metabolic panel, complete blood count with differential, and antiseizure medication levels, will be monitored at baseline, 1.5 months, and at the end of 3 months.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Conditions

Epilepsy Dravet Syndrome Lennox-Gastaut Syndrome Tuberous Sclerosis Focal Seizures

Interventions

TurmericDIETARY_SUPPLEMENT

Twenty patients will be enrolled and treated with a stable dose of orally administered turmeric oil daily for 3 months.

Eligibility

Sex: ALLMin age: 1 YearMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with greater than greater than six seizures per month diagnosed with Dravet Syndrome, Lennox-Gastaut Syndrome, Tuberous Sclerosis, or focal seizures followed at NYU CEC. Exclusion Criteria: * Patients expected to have changes to any medications or supplements during study period * exposure to any investigational agent in the month prior to study entry * pregnant or breast feeding women, positive pregnancy test * history of non-compliance * known drug or alcohol dependence * known baseline hematologic * liver function * renal function * absorption * absorption

Locations (1)

New York University School of Medicine

New York, New York, United States

Outcomes

Primary Outcomes

Number of epilepsy patients enrolled in study

feasibility of recruiting patients into a prospective study designed to evaluate the effect of orally ingested turmeric oil on seizures.

Time frame: 3 months

Secondary Outcomes

Number of epilepsy seizures post epilepsy treatment with turmeric

Time frame: 3 months

Data from ClinicalTrials.gov

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