Evaluate the Safety of BEL-X-HG in Advanced Cancer Patients

Inclusion Criteria: 1. Male or female patients of age ≥20 years 2. Pathologically or cytologically confirmed advanced refractory solid tumors for which standard therapy proven to provide clinical benefit does not exist or is no longer effective. It is acceptable for HCC subjects with Child Pugh stage A to confirm diagnosis of the advanced refractory solid tumors by imaging (CT scan). 3. Evaluable disease, at least one measurable target lesion on imaging by RECIST 1.1 (Response Evaluation Criteria in Solid Tumors) criteria. 4. Eastern Cooperative Oncology Group (ECOG) performance score ≤ 2 5. Life expectancy ≥ 3 months 6. Patients able to swallow and retain orally administered medication and does not have any clinically significant gastrointestinal abnormalities that may alter absorption such as malabsorption syndrome or major restriction of the stomach or bowels 7. Laboratory values at screening and baseline (Day 1) of: * Absolute neutrophil count (ANC) ≥ 1,500 /mm3 * Platelets ≥ 75,000 /mm3 * Hemoglobin (Hb) ≥ 8.5 g/dL * Serum creatinine (Cr.) ≤1.5 mg/dL or estimated Glomerular Filtration Rate (eGFR) ≥ 60 mL/min/1.73 m2. MDRD Study equation: eGFR = 186 x (SCr)\^-1.154 x (age)\^0.203 x (0.742 if female) x (1.210 if African American) SCr: serum creatinine in mg/dL; age: in year 8. Patients with primary liver cancer or hepatic metastasis are eligible to enroll, provided that, at screening and baseline (Day 1), the following criteria are met: * Total bilirubin (T-Bil) ≤2.0 mg/dL * AST and ALT ≤ 5 times the institutional upper limit of normal * Child-Pugh Class A; (Score ≤6) * Serum albumin ≥2.8 g/dL 9. Patients with a history of esophageal bleeding have varices that have been sclerosed or banded and no bleeding episodes have occurred during the prior 6 months 10. If history of brain metastases treated with radiation therapy, radiation therapy is required to be completed at least 3 months prior to enrolment and metastasis achieve stable disease (SD) since radiation completion 11. Must have recovered from toxicities of previous anti-cancer treatments to NCI-CTCAE version 4.03 grade 1 or lower, except for alopecia 12. Females patient must be either of non-childbearing potential, i.e. surgically sterilized (e.g. tubal ligation, hysterectomy, or ovariectomy) or one year post- menopausal; or, if of childbearing potential, confirmed not pregnant at screening and use of two adequate contraceptive precautions (as per investigator) i.e. condoms plus oral contraceptives or condoms plus endometrial contraceptive devices, during the entire treatment period of this study and for 6 months after exiting from the study 13. Male patients with female partners of childbearing potential must be willing to use a reliable form of contraception (condoms), from screening until 6 months after existing from the study 14. Given signed and dated written informed consent and willing/able to comply with all protocol required visits/procedures Exclusion Criteria: 1. Primary major surgery \< 4 weeks prior to the planned first study treatment day 2. Lactating or pregnant women or plans to be become pregnant 3. Except for alopecia, any drug-related AE from any previous treatments not recovered to NCI-CTCAE version 4.03 grade 1 or lower prior to the planned first study treatment day 4. With active systemic infections, active and clinically significant cardiac diseases, active gastrointestinal diseases, active pulmonary diseases, or medical conditions that may significantly affect adequate absorption of investigational product. 5. Known allergy to BEL-X-HG or its formulation excipients 6. History of autoimmune disease that in the investigator's opinion may be significant to exclude participation in the study 7. Use of any investigational agents or non-registered product within 4 weeks of baseline 8. Known human immunodeficiency virus (HIV) positivity 9. Known hepatitis B virus (HBV) or hepatitis C virus (HCV) carrier who has: * serum HBV DNA \> 2,000 IU/mL and abnormal ALT (\> 5 ULN) (for HBV carrier) * abnormal ALT (\> 5 ULN) (for HCV carrier) 10. With conditions, judged by the investigator, as unsuitable for the study 11. Mean QTc with Fridericia's correction (QTcF\*) greater than 450 ms in screening ECG or history of familial long QT syndrome \*: Fridericia's formula: 12. Any cancer-directed therapy (chemotherapy, radiotherapy, biological or immunotherapy, etc.) within 4 weeks or 5 half-lives, (whichever is shorter) of baseline