Retrospective cohort analysis of children hospitalized for pneumonia comparing disease severity on admission, clinical course, treatment and outcomes and prospective telephone based Follow-Up assessement.
The investigators will conduct a retrospective cohort analysis of children hospitalized for pneumonia at the Filderklinik between December 2006 and November 2010. The Bacterial Pneumonia Score, a validated composite laboratory, clinical and radiologic score developed by Moreno et al, will be retrospectively applied to define cases as either viral or bacterial pneumonia. The investigators will compare disease severity on admission, clinical course, and outcomes (in terms of complications, length of stay and readmission rates) between antimicrobial and non-antimicrobial managed bacterial pneumonia cases. Long-term Follow-Up will be assessed by telephone interviews with the parents.
Study Type
OBSERVATIONAL
Enrollment
350
Drugs, external applications like chest wraps, inhalations
Arcim Institute
Filderstadt, Baden-Wurttemberg, Germany
Cure rate of non-antimicrobial management of bacterial pneumonia
Cure rate of non-antimicrobial management of bacterial pneumonia (in the following and in the final publication, the term "bacterial pneumonia" will be used for children who fulfill the Moreno criteria for pneumonia): % of children managed without antimicrobials since admission, without subsequent need for antimicrobials or readmission.
Time frame: Between admission and 3 months after discharge
Medical complication rate
Medical complication rate among children with bacterial pneumonia, treated with or without antimicrobials
Time frame: Between admission and 3 months after discharge
Length of hospital stay
Length of hospital stay for children with bacterial pneumonia, managed with or without antimicrobials
Time frame: Between admission and 3 months after discharge
Readmission rate
Readmission rate for pneumonia among children with bacterial pneumonia, managed with or without antimicrobials
Time frame: 7 - 10 years after hospitalization
Temperature normalization
Days to temperature normalization (\< 38°C) in children with bacterial pneumonia, managed with or without antimicrobials
Time frame: Between admission and 3 months after discharge
Days of supplemental oxygen need
Days of supplemental oxygen need in children with bacterial pneumonia, managed with or without antimicrobials
Time frame: Between admission and 3 months after discharge
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Changes in respiratory rate
Changes in respiratory rate as an indicator for pulmonary infection
Time frame: Between admission and 3 months after discharge
Changes in Bacterial Pneumonia Score
Changes in Bacterial Pneumonia Score as an indicator for pulmonary infection
Time frame: Between admission and 3 months after discharge
Changes in oxygen saturation
Changes in oxygen saturation as an indicator for pulmonary infection
Time frame: Between admission and 3 months after discharge
Changes in CRP
Changes in CRP as an indicator for infection
Time frame: Between admission and 3 months after discharge
Changes in leukocyte count
Changes in leukocyte count as an indicator for infection
Time frame: Between admission and 3 months after discharge
Changes in pH
Changes in pH as an indicator for respiratory distress
Time frame: Between admission and 3 months after discharge
Changes in pCO2
Changes in pCO2 as an indicator for respiratory distress
Time frame: Between admission and 3 months after discharge
Rate of chronic and acute-infectious co-morbidities
Rate of chronic and acute-infectious co-morbidities on admission in children with bacterial pneumonia, subsequently managed with or without antimicrobials
Time frame: Day of admission
Utilization rate of a package of complementary treatment measures
Utilization rate of a package of complementary treatment measures from anthroposophic medicine (including oral medications, inhalation and external nursing applications) in children managed with or without antimicrobials
Time frame: Between admission and 3 months after discharge
Antimicrobial treatment rate in children with viral pneumonia
Antimicrobial treatment rate in children classified as viral pneumonia by Bacterial Pneumonia Score
Time frame: Between admission and 3 months after discharge
Number of patients treated with antipyretics
Number of patients treated with antipyretics
Time frame: Between admission and 3 months after discharge