High Resolution Micro OCT Imaging

N/AActive Not RecruitingNCT03256773

University of Alabama at Birmingham60 enrolled

Overview

The purpose of this study is to learn about using the imaging to make images of the lungs and nose with the long-term goal of the research leading to potential treatments and new therapies for patients with cystic fibrosis.

Lung Disease is the predominate cause of morbidity and mortality in patients with cystic fibrosis (CF). A better understanding of the primary pathogenesis of CF is essential in order to reveal the features that may lead to the onset of progressive lung disease. Discerning the nature of the CF defect could resolve longstanding controversy and result in a new therapeutic opportunity that may address pathophysiology. Recently the investigators have developed an innovative technology, termed 1-µm resolution optical coherence tomography (µOCT), which enables real-time cross-sectional microscopy of the functional epithelial surface of living airways.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cystic Fibrosis COPD PCD - Primary Ciliary Dyskinesia Covid19 Sinusitis

Eligibility

Sex: ALLMin age: 14 YearsHealthy volunteers:

Medical Language ↔ Plain English

THE INCLUSION CRITERIA: * Patients diagnosed with CF or healthy normal controls with no respiratory disease * Patients must be over the age of 14 * Patient must be able to give informed consent THE EXCLUSION CRITERIA: * Patients with recent respiratory infection requiring antibiotics or corticosteroids in the last 4 weeks (excluding routine perioperative antibiotics) * Patients with major sinus surgery that will alter the nasal anatomy and preclude imaging of the nares * Any condition that in the opinion of the investigator will alter the safety of pilot testing in the operating room * Female subjects who are pregnant

Locations (1)

University of Alabama at Birmingham

Birmingham, Alabama, United States

Outcomes

Primary Outcomes

feasibility of uOCT probe

to determine if a uOCT probe can image airway epithelial cells from the lung and the nares of adult patients

Time frame: 1 year

Data from ClinicalTrials.gov

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